Karthus Build / Runes
Late Game Items
Spell Skill Priority
Mobalytics Karthus RunesMore Karthus Builds
lolvvv Karthus RunesKarthus Runes
Ask your allies to help point out when you should use Requiem to get kills in different lanes.
Lay Waste is very strong at farming minions and harassing enemy champions.
Karthus Runes can cast spells for a short duration after he is killed. Move away from his corpse to be safe.
Make sure you always have enough health to survive Requiem, even if you have to go back to the base more frequently to heal.