Cassiopeia Build / Runes
3

Cassiopeia Build / Runes

the Serpent's Embrace • Platinum+
Best Cassiopeia Build on Mid for patch 12.22. Find the Cassiopeia Runes you are looking for!
2.6%
Pick Rate
50.9%
Win Rate
1.9%
Ban Rate
2.4K
Matches

Strong against

Weak against

Summoner Spells

Flash
Teleport
51.8%
884 Matches

Starter Items

Health Potion
2
Tear of the Goddess
51.0%
1,894 Matches

Core Items

Rod of Ages
Archangel's Staff
Rylai's Crystal Scepter
59.1%
330 Matches

Late Game Items

Abyssal Mask
Zhonya's Hourglass
Rabadon's Deathcap
72.7%
58.8%
58.0%

Spell Skill Priority

Twin Fang
E
Noxious Blast
Q
Miasma
W
56.1%
576 Matches
Noxious Blast
2
8
10
12
13
 
Miasma
4
14
15
 
Twin Fang
1
3
5
7
9
 
Petrifying Gaze
6
11
 

Mobalytics Cassiopeia Runes

More Cassiopeia Builds
Precision

Precision

Press the Attack
Lethal Tempo
Fleet Footwork
Conqueror
Overheal
Triumph
Presence of Mind
Legend: Alacrity
Legend: Tenacity
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
Resolve

Resolve

Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching
Offense
Offense
Defense
Offense
Flex
Flex
Offense
Flex
Flex

lolvvv Cassiopeia Runes

Cassiopeia Runes
Precision

Precision

Press the Attack
0%
Lethal Tempo
0%
Fleet Footwork
0%
Conqueror
100%
Overheal
0%
Triumph
0%
Presence of Mind
100%
Legend: Alacrity
0%
Legend: Tenacity
100%
Legend: Bloodline
0%
Coup de Grace
0%
Cut Down
0%
Last Stand
100%
Sorcery

Sorcery

Nullifying Orb
0%
Manaflow Band
100%
Nimbus Cloak
0%
Transcendence
100%
Celerity
0%
Absolute Focus
0%
Scorch
0%
Waterwalking
0%
Gathering Storm
0%
Offense
33%
Offense
100%
Defense
0%
Offense
0%
Flex
0%
Flex
0%
Offense
67%
Flex
0%
Flex
100%

Lore

Ally Tips

Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.

Lead your enemy when targeting with Noxious Blast to ensure the hit.

Enemy Tips

Be wary of Cassiopeia Runes's damage potential with Twin Fang when she has you poisoned.

Turn away from Cassiopeia Runes when she is casting Petrifying Gaze to get slowed instead of stunned.

Cassiopeia Runes is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power. There, she was bitten by a gruesome tomb guardian, whose venom transformed her into a viper-like predator. Cunning and agile, Cassiopeia Runes now slithers under the veil of night, petrifying her enemies with her baleful gaze.