
3
Cassiopeia Build / Runes
the Serpent's Embrace • Platinum+
Best Cassiopeia Build on Mid for patch 12.12. Find the Cassiopeia Runes you are looking for!
2.6%
Pick Rate
51.9%
Win Rate
2%
Ban Rate
37.8K
Matches
Summoner Spells


52.5%
9,191 Matches
Starter Items

2

52.0%
30,831 Matches
Core Items



57.4%
6,970 Matches
Late Game Items



55.1%
63.7%
60.4%
Spell Skill Priority

E

Q

W
52.9%
19,708 Matches
![]() | 2 Q | 8 Q | 10 Q | 12 Q | 13 Q | |||||||||||
![]() | 3 W | 14 W | 15 W | |||||||||||||
![]() | 1 E | 4 E | 5 E | 7 E | 9 E | |||||||||||
![]() | 6 R | 11 R |
Mobalytics Cassiopeia Runes
More Cassiopeia Builds
Precision

Press the Attack

Lethal Tempo

Fleet Footwork

Conqueror

Overheal

Triumph

Presence of Mind

Legend: Alacrity

Legend: Tenacity

Legend: Bloodline

Coup de Grace

Cut Down

Last Stand

Resolve

Demolish

Font of Life

Shield Bash

Conditioning

Second Wind

Bone Plating

Overgrowth

Revitalize

Unflinching









lolvvv Cassiopeia Runes
Cassiopeia Runes
Precision

0%
Press the Attack

0%
Lethal Tempo

0%
Fleet Footwork

100%
Conqueror

0%
Overheal

0%
Triumph

100%
Presence of Mind

0%
Legend: Alacrity

100%
Legend: Tenacity

0%
Legend: Bloodline

50%
Coup de Grace

0%
Cut Down

50%
Last Stand

Resolve

0%
Demolish

0%
Font of Life

0%
Shield Bash

21%
Conditioning

0%
Second Wind

79%
Bone Plating

57%
Overgrowth

0%
Revitalize

43%
Unflinching

52%

100%

5%

0%

0%

24%

48%

0%

71%
Lore
Ally Tips
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Enemy Tips
Be wary of Cassiopeia Runes's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia Runes when she is casting Petrifying Gaze to get slowed instead of stunned.
Cassiopeia Runes is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power. There, she was bitten by a gruesome tomb guardian, whose venom transformed her into a viper-like predator. Cunning and agile, Cassiopeia Runes now slithers under the veil of night, petrifying her enemies with her baleful gaze.