
2
Cassiopeia Build / Runes
the Serpent's Embrace • Platinum+
Best Cassiopeia Build on Mid for patch 13.3. Find the Cassiopeia Runes you are looking for!
3.4%
Pick Rate
52.6%
Win Rate
4.1%
Ban Rate
10.2K
Matches
Summoner Spells


53.6%
1,892 Matches
Starter Items

2

52.5%
8,668 Matches
Core Items



57.3%
2,872 Matches
Late Game Items



64.6%
59.2%
58.6%
Spell Skill Priority

E

Q

W
56.7%
2,488 Matches
![]() | 2 Q | 8 Q | 10 Q | 12 Q | 13 Q | |||||||||||
![]() | 4 W | 14 W | 15 W | |||||||||||||
![]() | 1 E | 3 E | 5 E | 7 E | 9 E | |||||||||||
![]() | 6 R | 11 R |
Mobalytics Cassiopeia Runes
More Cassiopeia Builds
Precision

Press the Attack

Lethal Tempo

Fleet Footwork

Conqueror

Overheal

Triumph

Presence of Mind

Legend: Alacrity

Legend: Tenacity

Legend: Bloodline

Coup de Grace

Cut Down

Last Stand

Sorcery

Nullifying Orb

Manaflow Band

Nimbus Cloak

Transcendence

Celerity

Absolute Focus

Scorch

Waterwalking

Gathering Storm









lolvvv Cassiopeia Runes
Cassiopeia Runes
Precision

0%
Press the Attack

0%
Lethal Tempo

0%
Fleet Footwork

100%
Conqueror

0%
Overheal

1%
Triumph

99%
Presence of Mind

1%
Legend: Alacrity

99%
Legend: Tenacity

0%
Legend: Bloodline

51%
Coup de Grace

1%
Cut Down

47%
Last Stand

Sorcery

0%
Nullifying Orb

86%
Manaflow Band

9%
Nimbus Cloak

58%
Transcendence

1%
Celerity

0%
Absolute Focus

42%
Scorch

0%
Waterwalking

4%
Gathering Storm

40%

100%

5%

8%

0%

40%

53%

0%

55%
Lore
Ally Tips
Use Twin Fang on poisoned stationary targets like monsters and units stunned by her Petrifying Gaze for maximum damage.
Lead your enemy when targeting with Noxious Blast to ensure the hit.
Enemy Tips
Be wary of Cassiopeia Runes's damage potential with Twin Fang when she has you poisoned.
Turn away from Cassiopeia Runes when she is casting Petrifying Gaze to get slowed instead of stunned.
Cassiopeia Runes is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power. There, she was bitten by a gruesome tomb guardian, whose venom transformed her into a viper-like predator. Cunning and agile, Cassiopeia Runes now slithers under the veil of night, petrifying her enemies with her baleful gaze.